Sodium Hyaluronate
Sodium hyaluronate is the sodium salt form of hyaluronic acid, also known as sodium hyaluronate (commonly called hyaluronic acid). It is a glucuronic acid-based polysaccharide, a natural polysaccharide widely present in the connective tissue, skin, eyes, and joint fluid of the human body. In terms of physical properties, it exhibits excellent optical transparency, remaining clear and transparent in solution; it also possesses typical non-Newtonian fluid characteristics, meaning its viscosity changes with the shear rate. In terms of chemical properties, the hydroxyl and carboxyl functional groups in its molecule give it a certain degree of chemical reactivity.
The performance and application effects of sodium hyaluronate are closely related to its physicochemical properties, which can be quantitatively evaluated through a series of key parameters.
| Parameter Categories | Specific Parameters | Detection Methods/Standards | Requirements | Application Relevance |
| Molecular Weight Distribution | Average Molecular Weight (kDa) | Gel Permeation Chromatography (GPC) | Cosmetic grade: 10-2000 kDa | Higher molecular weight correlates with stronger moisturizing/supportive properties; lower molecular weight offers better penetration. |
|---|---|---|---|---|
| Viscosity | Solution Viscosity (mPa·s) | Rotational Viscometer (e.g., Brookfield) | Pharmaceutical grade: ≥1000 kDa | Viscosity is positively correlated with molecular weight, affecting product user experience (e.g., injection resistance). |
| Purity | Protein Residue (%) | High-Performance Liquid Chromatography (HPLC) | 1% solution: 1000-10000 mPa·s (high molecular weight) | Low purity may lead to allergies or irritation. |
| Endotoxin Content | Endotoxin (EU/mg) | Limulus Amebocyte Lysate Test (LAL Test) | Pharmaceutical grade: ≥95% | Excessive endotoxins may trigger inflammatory reactions. |
| pH Value | Solution pH | pH Meter | Cosmetic grade: ≥90% | Deviation in pH may lead to degradation or skin irritation. |
| Degree of Crosslinking | Crosslinking Agent Residue (ppm) | Liquid Chromatography-Mass Spectrometry (LC-MS) | Pharmaceutical grade: <0.1 EU/mg | Excessive crosslinking agent residue may pose a toxicity risk. |
| Microbial Limits | Total Bacterial Count (CFU/g) | Pharmacopoeia Methods (e.g., USP <61>) | Cosmetic grade: <0.5 EU/mg | Excessive microorganisms may lead to infection risk. |
| Heavy Metal Content | Lead/Arsenic/Mercury (ppm) | Atomic Absorption Spectrometry (AAS) | Physiological range: 6.0-7.5 | Excessive heavy metals may lead to cumulative toxicity. |
| Moisture Content | Loss on Drying (%) | Constant Temperature Drying Method | BDDE residue: <2 ppm (cross-linked HA) | High moisture content affects stability and promotes microbial growth. |
| Transparency | Transmittance (%) | Spectrophotometer (400-700 nm wavelength) | Pharmaceutical grade: <100 CFU/g | Low transparency may affect product appearance (e.g., injectable gels). |
High Molecular Weight (>1000 kDa):
Characteristics: Strong film-forming ability, high viscosity, not easily absorbed into the skin.
Applications: Surface moisturizing, joint lubricant, ophthalmic viscoelastic agent.
Medium Molecular Weight (200-1000 kDa):
Characteristics: Moderate permeability, combines moisturizing and repairing functions.
Applications: Deep hydrating serums, wound healing accelerators.
Low Molecular Weight (10-200 kDa):
Characteristics: High transdermal absorption rate, can penetrate the dermis.
Applications: Anti-aging products, repairing damaged skin.
Oligomeric (<10 kDa):
Characteristics: Extremely small molecular weight, can penetrate cell membranes.
Applications: Anti-inflammatory, antioxidant, promotes collagen synthesis.
Medical Aesthetics and Skincare
Pharmaceutical Field
Food and Health Supplements
Industrial Uses
Sodium hyaluronate, with its excellent moisturizing properties, biocompatibility, and versatility, has become a core ingredient in medical aesthetics, pharmaceuticals, and food industries. Through molecular weight control and chemical modification, it can meet diverse needs ranging from surface hydration to deep tissue repair. CD BioSustainable provides high-purity, low-endotoxin sodium hyaluronate raw materials, strictly complying with pharmaceutical-grade standards, supporting the sustainable development of medical aesthetics, joint treatment, and biomaterials fields.
If you are interested in our products, please feel free to contact us at any time to obtain more detailed product information and professional consultation services.
Our products and services are for research use only and cannot be used for any clinical purposes.
