Environmental Material Ecotoxicity Assessment is a multidisciplinary scientific endeavor aimed at evaluating the potential adverse effects of environmental materials—ranging from industrial chemicals and pollutants to novel biodegradable substances—on living organisms and ecosystems. This assessment is pivotal in understanding the ecological risks associated with these materials, guiding regulatory frameworks, and fostering the development of sustainable and environmentally benign alternatives. By scrutinizing how materials interact with biological entities at various levels, from cellular to ecosystemic, researchers can predict and mitigate potential environmental harm, ensuring the preservation of biodiversity and ecosystem health.