Biocompatibility Testing

Due to the rapid increase in the use of biological entities in the medical, biotechnological, pharmaceutical, and other disciplines, there has been an increased focus on biomaterials compatibility. To make sure the biomaterials can be safely and effectively used, testing for compatibility becomes an important step.

CD BioSustainable-Advanced Materials is the industry's leader in advanced material products and services, and it specializes in biocompatibility testing services. Our goal is to safeguard materials used in biomedical applications and assist customers in satisfying worldwide biocompatibility norms and regulations during the design and construction phases of their projects.

Importance of Biomaterial Compatibility Testing

The term biocompatibility refers to the extent of the acceptability of a biomaterial within the human biological environment or its ability to contact human tissue in a manner that does not evoke any adverse reaction or result in the destruction of human tissue. The aim of biomaterials compatibility testing is to investigate the degree of integration or acceptance of materials into the biological environment to predict their possible biological response in the human body, and their effect on living organisms. Compatibility testing reduces the risks and assures the effective and safe utilization of biomaterials.

Our Services

Fig.2 Our cytotoxicity testing service for advanced materials.

Cytotoxicity Testing

Cytotoxicity is evaluated when a biomaterial is placed in a cell culture system and these cells' responses towards the material are assessed. Implantable material cytotoxicity can be determined using probes of common techniques such as cell proliferation assay, cell morphology characterization, and apoptotic assay.

Fig.3 Our allergenicity testing service for advanced materials.

Allergenicity Testing

By testing whether the biological material causes allergic reactions, we can assess the sensitization of the material. Common sensitization tests include skin irritation test, skin sensitization test, oral irritation test, rectal irritation test, and eye irritation test.

Fig.4 Our implantation testing service for advanced materials.

Implantation Testing

We can observe the response of the materials to animal tissues and evaluate the biocompatibility of the materials implanting biomaterials into animals. Implantation tests are usually categorized into subcutaneous implantation, muscle implantation, and bone implantation.

Fig.5 Our blood compatibility testing service for advanced materials.

Blood Compatibility Testing

Through testing the interaction of the biomaterial with blood, we can evaluate the blood compatibility of the material. Common blood compatibility tests include coagulation test, hemolysis test, and platelet activation test.

Our Preclinical Animal Testing Platform

We have a specialized biocompatibility testing platform designed to provide comprehensive support for the safety assessment of medical devices and biomaterials. This platform is also equipped for systematic research on genetically modified animals, providing technical and facility support for research on novel biomaterials.

Animal Types	Applications
Dog	Cardiovascular devices/materials and cardiac electrophysiology.
Sheep	Ophthalmology, plastic surgery, and orthopedic instruments/materials.
Goat	Plastic surgery and neuromodulation devices/materials.
Pig	Cardiovascular devices/materials.
Rabbit	General implant effects (subcutaneous/muscle implants), orthopedic instruments/materials, and tendon repair materials.
Rat	Toxicological reactions and general implantation effects (subcutaneous/muscular implantation).
Guinea Pig	Toxicological reactions and general implantation effects (subcutaneous/muscular implantation).

Our Testing Capabilities

Wide Range of Tests
In addition to cytotoxicity tests, sensitization tests, implantation tests, and blood compatibility tests, we offer a wide range of biocompatibility testing services including systemic toxicity tests, genotoxicity tests, carcinogenicity and reproductive toxicity tests.
Pre-clinical Research Support
From the development of prototype materials and unexplored mechanisms to performance evaluation, device sterility, and biocompatibility tests, we offer device firms pre-clinical study help.
Advanced Testing Equipment
Our laboratories are furnished with the latest and advanced testing gadgets that include infrared spectrometers, scanning electron microscopes, and thermogravimetric analyzers. Such devices have made it easier for us to determine the biocompatibility of various materials.
Professional Technical Team
Our team of experts has both considerable professional experience and knowledge enabling them to evaluate evaluation test items specific to a product's intended use and its interaction with the human body.

CD BioSustainable-Advanced Materials is dedicated to ensuring that our clients fully understand the range and complexity of the biocompatibility testing services we provide. We assist clients with developing a scientific rationale for their medical devices, implants, and biomaterials assisting in bringing the devices to market with confidence in safety and efficacy in practice. Those who require biocompatibility testing should not hesitate to contact us for additional details and an official estimate.

For Research or Industrial Raw Materials, Not For Personal Medical Use!