New Material Evaluation Based on Organoids

At the forefront of advanced materials research, organoid technology is rapidly revolutionizing traditional research models. Currently, scientists have successfully cultivated various organoids, such as the brain, intestine, and liver, providing brand-new research tools for advanced materials evaluation, personalized medicine, and regenerative medicine.

CD BioSustainable-Advanced Materials is an innovative company specializing in advanced materials R&D and evaluation, committed to providing clients with comprehensive new material evaluation services based on organoid technology. Relying on an advanced organoid modeling and identification platform, we are able to highly simulate the microenvironment of human tissue and provide accurate evaluations of the safety, biocompatibility, and functionality of new materials.

Organoid Technology: A New Frontier in Life Simulation

Organoids are self-derived, multicellular, three-dimensional tissues that form from self-cell cultures, serving as superior substitutes for animal models. Unlike organoids, two-dimensional cell models are bound to shorter lifespans as well as face a multitude of ethical concerns related to animal testing. In addition to these benefits, organoids are far closer to real organs as they contain distinct features of specific organs. Since organoids contain a considerable variety of diverse cells, they replicate the structure and complexity of true organs with great accuracy.

Fig. 1 Organoid formation diagram. Fig. 1 Schematic diagram of organoid formation. (Unagolla JM, Jayasuriya AC, 2022)

Organoid Models Suitable For Different Materials

Organoid Models	Material Types	Testing Indicators
Intestinal organoids	Drug carriers	Mucosal permeability, intestinal barrier integrity (TEER)
	Nanoparticles	Cell uptake efficiency, tight junction protein expression
	Food additives	Inflammatory factors (IL-8), apoptosis markers
Liver organoids	Biodegradable scaffolds	Albumin secretion, urea cycle function
	Industrial chemicals	CYP450 enzyme activity, degree of fatty degeneration
	Drug sustained-release materials	Metabolite accumulation, bile duct network integrity
Skin organoids	Medical dressings	Stratum corneum regeneration rate, collagen deposition
	Cosmetic ingredients	Melanin production, TRPV1 receptor activation
	Transdermal administration systems	Permeability coefficient, Langerhans cell activation
Lung organoids	Air purification materials	Cilia beating frequency, mucus secretion volume
Lung organoids	Inhaled nanoparticles	Alveolar macrophage phagocytic activity
Heart organoids	Conductive biomaterials	Calcium transient frequency, beating synchrony
	Drug-coated stents	Risk of QT interval prolongation
	Environmental remediation materials	Myocardial cell apoptosis rate

Our Services

Organoid Modeling Service

We offer precise and comprehensive multi-lineage organoid model construction and organoid culture, all while recapitulating human microenvironments, facilitating scientific research and material innovation.

Tailored Organoid Culture: Organize and create organoid designs from specified tissues based on client specifications to imitate the organ's structural and functional features.
Organoid Phenotype Analysis: Analyze organoid shape and phenotypic features, gene expression, and metabolic activities using high-throughput imaging, single-cell sequencing, and immunofluorescence staining.

Organoid-based New Material Evaluation Service

Using organoid models, we provide full scientific evaluation services to assist clients in understanding more about the safety, biocompatibility, and functionality of new materials. Our services include the following:

Biocompatibility Testing

Cytotoxicity Assessment: Determine the toxic effects of materials from a biological and cellular perspective using cell viability assays, apoptosis assays, and other methodologies.
Inflammatory Response Assessment: Determine whether new materials elicit inflammatory responses, including secretion of inflammatory factors and immune cell infiltration.
Tissue compatibility assessment: Determine whether new materials elicit tissue injury or abnormal responses.

Functional Impact Research

Physiological Function Assessment: Evaluate the effects of new materials on the organoid's physiological functions, including its metabolic, secretory, and electrophysical functions.
Cumulative Effect Assessment: Assess the effects of new materials over time, including the cell's growth, differentiation, and tissue structural modifications.

Personalized Assessment Plan

Experimental Plan Customization: Tailor-made experimental strategies to meet customers' requirements, such as materials, organoid models, duration of the experiment, etc.
Reporting: Analyze the data and prepare detailed reports to include experiment results, data, analysis charts, conclusions, and recommendations.

Applications

Medical Device and Biomaterial

Implant material safety testing
Nanomaterial toxicology research

Cosmetics and Skincare

Ingredient safety assessment
Transdermal absorption research

Environment and Chemistry

Material toxicity screening
Material environmental evaluation

Using our innovative organoid technology platform, CD BioSustainable-Advanced Materials assists clients in accelerating R&D cycles, cutting down testing expenses, and offering dependable data during the new material development phase, which simulates the human body's response more precisely. Should you have any questions, do not hesitate to contact us to learn more about our offerings.

Reference

Unagolla JM, Jayasuriya AC. Recent advances in organoid engineering: A comprehensive review. Appl Mater Today. 2022; 29:101582.

For Research or Industrial Raw Materials, Not For Personal Medical Use!