logo

Amide Bond Formation Design Service

The amide bond holds importance as a significant component of structural organic and biomolecules and is also essential in medicine. Hence, amide bond formation is of great interest in organic chemistry, biochemistry, and medicinal chemistry.

CD BioSciences-GreenChemistry is a company that specializes in green chemistry and is committed to offering clients direct and environmentally safe amide bond formation. Our team is composed of professionals who have worked at the cutting edge of green chemistry for a considerable amount of time. This combination of rich experience and innovation enables them to assist clients in designing novel catalytic systems and reaction conditions.

Why Green and Efficient Construction of Amide Bonds?

The amide bond formation reaction is essential in peptide synthesis and medicinal chemistry investigations. Conventional methods of amide bond construction have been found to use far too many reagents as well as large quantities of solvents, thus posing a very serious risk to the environment and human health. For these reasons, there is still an ongoing considerable amount of research on the development of novel environmentally friendly acylation reagents and efficient methods for the selective synthesis of amides.

Conventional methods of amide bond synthesis have the following limitations:

  • Environmental Risks: The use of condensation agents such as EDC and DCC, which are often regarded as toxic or expensive, are potential sources of environmental pollution as well as poor health.
  • Poor Atomic Economy: Conventional methods put more demands than bases as some put additional reagents to try and neutralize the reaction by-products, thus increasing waste.
  • Harsh Reaction Conditions: Some methods require high temperatures, high pressures or strong oxidizing agents, and high energy consumption.

Green Construction Methods of Amide Bonds

Elemental Organics Catalytic

Elemental organics (e.g., boron, silicon, aluminum, etc.) as catalysts show unique advantages in amide bond synthesis, avoiding the use of traditional metal catalysts, and reducing toxicity and waste generation.

Green Solvents and Reagents

Water as a green solvent is widely used in the direct synthesis of amide bonds, avoiding the use of organic solvents and reducing the environmental impact. In addition, the construction of amide bonds without metal participation was realized by using photo/electrical redox to generate free radicals.

Mechanochemistry and Microwave Technology

Promoting the reaction by mechanical force without solvents or additives can significantly improve the reaction efficiency and atom economy. In addition, through microwave-assisted catalysis, amides are synthesized directly from carboxylic acids and amines under solvent-free conditions, with fast reaction speeds, high yields, and low waste.

Biocatalysis

The development of biocatalytic technology provides a more economical and green synthetic method for the construction of amide bonds. The utilization of enzymes as catalysts is highly selective and environmentally friendly. For example, amides are efficiently synthesized in aqueous media using lipases.

Our Amide Bond Formation Design Service

Amide Bond Green Synthesis Process Development

  • Customized Reaction Solutions: We develop and refine amide bond-forming reactions to suit the specific requirements of our clients, optimizing such parameters as the temperature, pressure, and solvent to maximize the efficiency of the reaction in a green manner while fulfilling production demands.
  • Green Catalytic Technology: Numerous highly active green catalysts are being developed by us that are not only efficient and easily recovered but also cause the reaction rate and selectivity as well as the catalysts' activities to increase, significantly reduce the expenses of production and relieve the pollution issues from traditional catalysts.

Green Solvent and Medium Selection

  • Green Solvent Screening: We offer an extensive range of screening and practical application of new green solvents, such as supercritical carbon dioxide, ionic liquids, and water.  These solvents excel in low volatility, toxicity, and ease of recovery and significantly curtail the use of organic solvents, thus reducing environmental pollution.
  • Solvent-free Reaction Development: We also offer solvent-free reaction development services for specific amide bond formation reactions.  Using solid catalysts or a microwave, efficient synthesis without solvent is possible, streamlining the process and cutting expenses.

Applications

  • Pharmaceutical Industry

Amide bonds occupy an important position in drug molecules, and our green synthesis approach helps to improve the sustainability and economy of drug synthesis.

  • Peptide Synthesis

Amide bonding is one of the core reactions in peptide synthesis. Our services show great potential in peptide synthesis, especially in reducing by-products and improving reaction efficiency.

  • Materials Science

Amide bonds are also widely used in polymers and polymeric materials. Through our services, the efficiency of material preparation can be improved, and the environmental impact can also be reduced.

CD BioSciences-GreenChemistry offers bespoke services to clients for building amide bonds utilizing the green chemistry approach. We strive to meet the needs of our clients concerning eco-friendly, economical, and efficient chemical synthesis. Please feel free to contact us, and we will be happy to provide you with high-quality services to help you realize your sustainable development goals.

Our products and services are for research use only and cannot be used for any clinical purposes.