Crystallization-based Chemical Separation and Purification Service

The process of crystallization is used extensively in the fields of chemistry, pharmaceuticals, and materials science. It consists of controlled precipitation and recrystallization of solutes. CD BioSciences-GreenChemistry provides a range of advanced crystallization solutions for different industries such as pharmaceuticals, fine chemicals, environmental remediation, and renewable energy. Crucially, we focus on effectively and sustainably aiding our clients in separating and purifying chemicals.

Introduction to Crystallization

Crystallization technology is an important chemical unit operation that involves the precipitation of a solid substance from a vapor, solution, or melt in the form of crystals. Usually, only molecules or ions of the same kind can be arranged regularly, so the crystallization process is highly selective. Since the crystallization process is complex, the phenomenon of crystal clustering sometimes occurs.

Fig.1 The ROY molecule has several crystalline structures. Fig.1 Several crystalline structures of the ROY molecule. (Ziemecka, et al., 2019)

Types of Crystallization

Cooling Crystallization

This method involves gradually lowering the temperature of the solution to achieve a supersaturated state, particularly suitable for salt substances whose solubility decreases significantly with decreasing temperature.

Evaporative Crystallization

Evaporative crystallization relies on the partial vaporization of the solvent to drive the solution into a supersaturated state, making it ideal for salt substances whose solubility is relatively unaffected by temperature changes.

Vacuum Crystallization

In the process of vacuum crystallization conducted under vacuum conditions, part of the solvent is removed through adiabatic evaporation of the hot solution, while the heat carried away during evaporation reduces the solution's temperature, thereby promoting the precipitation of crystals.

Our Professional Services

The crystallization method we offer is an efficient and environmentally friendly separation and purification technology that not only achieves high-purity separation of substances but also reduces waste and energy consumption during operation, which is in line with the concept of sustainable development.

Dissolving the Solute

We add the chemical to be separated (solute) to an appropriate amount of solvent, heat, and stir the solution to saturate it and ensure that the solute is completely dissolved.

Control of Crystallization Conditions

Depending on the nature of the solute, we develop appropriate crystallization conditions, such as temperature, pressure, and type of solvent.

For substances that need to be crystallized by cooling, the temperature of the solution is gradually lowered so that it gradually becomes supersaturated and the solute begins to crystallize.
For substances that need to be crystallized by evaporation, the solution is supersaturated by evaporating part of the solvent, and crystals are precipitated.

Collection and Separation of Crystals

When a large number of crystals are precipitated, we separate the crystals from the solvent by filtration or centrifugation. The collected crystals are then washed to remove impurities and solvent residues adhering to the crystal surface.

Drying and Purification

We dry the washed crystals to remove residual moisture and solvents. In addition, depending on the specific needs of the client, we offer further purification operations such as recrystallization and zone melting to improve the purity and quality of the crystals.

Fig.2 We utilize the process of crystallization to isolate and purify chemical substances. Fig.2 Process of separating and purifying chemicals using crystallization. (CD BioSciences-GreenChemistry)

Applications

Drug R&D: Crystallization is used to separate active ingredients from mixtures and to improve the purity and quality of drugs.
Catalyst Preparation: The crystallization method can be used to purify and separate the active components of the catalyst.

Wastewater Treatment: The crystallization method can be used to purify wastewater containing soluble solid impurities, such as electroplating wastewater, and pharmaceutical wastewater.
Food Industry: The crystallization method can be used to extract and purify the nutrients in food.

Advantages

Professional Team: We have a team of senior chemical engineers and technical experts with rich practical experience and profound theoretical knowledge, who provide professional crystallization technical support for clients.
Innovative Technology: We continuously develop and innovate crystallization technology to help clients solve problems that are difficult to deal with by traditional crystallization methods, and to improve product purity and yield.
Green Chemistry: Throughout the crystallization process, we reduce the environmental impact by using non-toxic, biodegradable, or easily recyclable solvents.
Individualized Needs: We offer highly customized crystallization solutions, designed and optimized to meet specific client needs and material properties.

CD BioSciences-GreenChemistry is committed to leading the separation and purification of chemical substances by crystallization to new heights with its excellent professional team, cutting-edge technology, and one-stop customized service, and working together with clients for the future of pure chemistry. We sincerely invite partners from all walks of life to contact us at any time and start the pure journey of chemical separation and purification together.

Reference

Ziemecka I, Gokalp S, et al. Polymorph selection of ROY by flow-driven crystallization[J]. Crystals. 2019, 9(7): 351.

Our products and services are for research use only and cannot be used for any clinical purposes.