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Centrifugation-based Chemical Separation and Purification Service

Centrifugation is a technique that uses centrifugal force to separate two or more substances of different specific gravity. It is applied in the purification of biopharmaceutical protein macromolecules or the pinpoint separation of small molecule metabolites in chemical processes. CD BioSciences-GreenChemistry has sufficient centrifugation technology to respond to such requirements from clients, enabling them to realize new levels of efficiency and accuracy.

What Is The Centrifugal Method?

Centrifugation is the process of employing centrifugal force to separate materials of different specific gravity. A centrifuge, as well as other devices, is capable of achieving considerable angular speed, which can enable the centrifugal force to exceed the force of gravity, thereby facilitating the easy setting of a suspension in a solution. Because varying substances possess different masses, the centrifugal force acting on them is also dissimilar, so they will sediment at rates proportional to their mass.

Fig.1 Centrifugal separation method for solids.Fig.1 Method of centrifugal separation of solids. (Brouwers, 2023)

Based on the different techniques, centrifugation can be subdivided into differential centrifugation and density gradient centrifugation.

  • Differential Centrifugation: It refers to the use of low-speed and high-speed centrifugation alternately, with different strengths of the centrifugal force to make different densities of the material-graded separation method.
  • Density Gradient Centrifugation: It is also called zone centrifugation, which means that centrifugation is carried out in a medium with a continuous density gradient.

Our Professional Services

As a leader in the industry, CD BioSciences-GreenChemistry sustains clients by providing them with modern and patented centrifugation technologies to enable them to separate compounds. We provide such services to clients in the pharmaceutical, biotechnology, chemicals, food, and beverage industries and ensure accuracy and efficiency for every separation process.

Solid-Solid Separation

We use centrifugation to separate different solids. We separate particles by size by controlling the centrifugation time so that only large particles are precipitated in the solution instead of all particles.

Liquid-Liquid Separation

We use centrifugation for liquid-liquid separation based on the difference in density of the different liquid components. This means that when a mixture of liquids is centrifuged, the centrifugal force causes the denser components to move outward, while the less dense components stay further inward.

Gas-Gas Separation

We offer centrifugal technology to separate isotope mixtures in a gaseous state. Under the effect of centrifugal force during high-speed rotation, isotope mixtures in a gaseous state can be fully separated from each other.

Solid-Liquid Separation

We place a liquid mixture containing solid particles in a centrifuge. Under the action of centrifugal force, the solid particles, due to their higher density, move outward and are deposited, thus separating from the liquid.

Applications

  • Protein Purification in Biopharmaceuticals: The centrifugation technology we offer can be used to isolate and purify proteins and enzymes in biopharmaceuticals, enhancing the purity and potency of drugs.
  • Separation of Components in the Food Industry: In food processing, we offer centrifugation technologies for separating fat components in whey and increasing protein concentration.
  • Pollutant Treatment in Environmental Sciences: Our centrifugation technology separates suspended particles and pollutants in water samples, ensuring efficient wastewater treatment.
  • Separation of Mixtures in Chemical Production: Our centrifugation technology is used to purify organic solvents or catalysts, improving reaction efficiency and meeting the demands of complex chemical processes.

Advantages

  • Efficient Separation: The centrifugation technology we offer enables rapid and efficient compound separation in a short period, greatly improving experimental and production efficiency.
  • Precise Purification: We help clients achieve precise compound purification by setting precise centrifugation conditions to ensure high purity and consistency of the product.
  • Wide Applicability: Our services apply to the separation of a wide range of mixtures, including liquid-liquid, solid-solid systems, solid-liquid systems, and gas-gas systems.

The separation and purification of compounds by centrifugation provided by CD BioSciences-GreenChemistry is revolutionizing multiple industries with its efficiency, greenness, and precision. Whether in pharmaceutical, food, or environmental sciences, our superior technology ensures perfect purity and consistency in every separation. Feel free to contact us to start a new chapter in your compound purification journey.

Reference

  1. Brouwers, J. Innovative methods of centrifugal separation[J]. Separations. 2023, 10(3): 181.

Our products and services are for research use only and cannot be used for any clinical purposes.