C-O Coupling Reaction-based Catalyst and Ligand Screening Service

CD BioSciences-GreenChemistry is engaged in novel synthetic reaction design. We're devoted to offering clients cost-effective and C-O coupling reactions, and ligand and catalyst screening services using modern science and technology. Our team possesses deep academic understanding combined with extensive practical experience and integrates the newest developments in green chemistry to offer clients cost-effective and environmentally safe catalytic solutions. At the same time, due to the intelligence of modern experimental platforms and screening algorithms, the optimal ligands are readily available for most clients in order to improve reaction efficiency and selectivity.

Common Catalysts and Ligands for C-O Coupling Reactions

C-O coupling reactions are an important class of organic reactions, which are widely used in the fields of drug synthesis, natural product preparation and polymer materials. Common catalysts and ligands have been widely used and optimized in different researches.

Types	Examples
Common Catalysts	Palladium (Pd) Catalysts: Pd(PPh₃)₄ Widely used in C-O coupling reactions, especially the Buchwald-Hartwig reaction. Pd(OAc)₂ Often used to catalyze C-O bond formation in concert with ligands. Pd₂(dba)₃ is an efficient precursor catalyst for a wide range of coupling reactions.
	Copper (Cu) Catalysts: CuI is commonly used in Ullmann-type C-O coupling reactions and is less costly. Cu(OTf)₂ shows high activity under certain conditions.
	Nickel (Ni) Catalysts: Ni(cod)₂ is used in C-O coupling reactions, especially when synergized with azetidic ligands. NiCl₂ is economical and practical for some specific reactions.
	Other Metal Catalysts: Precious metal catalysts such as Au (gold) and Pt (platinum) are also used in some specific C-O coupling reactions.
Common Ligands	Nitrogen-oxygen Ligands: Nitrogen-oxygen ligands show good results in copper-catalyzed C-O coupling reactions.
	Oxalylhydrazine Ligands: Oxalylhydrazine ligands (e.g., L1) exhibit excellent performance in copper-catalyzed C-O coupling reactions, significantly extending catalyst life and increasing the TON of the reaction.
	Bidentate Ligands Bidentate ligands including o-phenanthroline, bipyridine, and diamine analogs are also widely used in copper-catalyzed C-O coupling reactions.
	Other Ligands: Anionic bidentate ligands (e.g., 1,3-dicarbonyl compounds, 8-hydroxyquinolines) have also been used in copper-catalyzed C-O coupling reactions.

Our C-N Coupling Reaction-based Catalyst and Ligand Screening Service

C-O Coupling Reaction Catalyst Customization and Development

We have a broad variety of catalysts which include transition metal catalysts like copper, gold, and palladium. We provide the most suitable catalysts in accordance with specific specifications and reaction systems for maximum efficiency and selectivity of the reaction.
In accordance with the principles of green chemistry, we strive to develop catalysts that are both recyclable and low in toxicity which helps reduce the generation of harmful by-products and the overall impact on the environment.
To enhance the level of compatibility between the catalyst and the reaction system, we guarantee a higher degree of satisfaction to our customers with customized catalyst synthesis services.

C-O Coupling Ligand Screening and Optimization

Ligand libraries of oxalyl hydrazine, nitrogen-oxygen, bidentate ligands, etc. can be quickly optimized for C-O coupling reactions due to our high throughput screening technology. Furthermore, we are able to fulfill our client's specific ligand requirements with ease.
Based on the screening results, we further optimize the structure and properties of the ligands to improve the activity, selectivity, and stability of the reaction.
The focus of our research is to develop green ligands that can reduce the consumption of solvents and the emissions of waste byproducts during the reaction.

Green Chemistry Solutions

From the initial stages of designing effective and eco-friendly catalysts to the final stages of ligand screening and optimization, we provide comprehensive service. We emphasize low energy and waste emissions and optimum reaction efficiency through the strict adherence to green chemistry methods that include the use of low-toxicity solvents and recyclable catalysts. Our clients achieve a sustainable synthesis reaction design with full assistance provided from laboratory to industrial scales to achieve breakthroughs in green chemistry.

Why Choose Us?

Green Chemistry Oriented

We strictly follow the principles of green chemistry to develop low-toxicity, recyclable catalysts, and environmentally friendly ligands to help our clients realize their sustainable development goals.

Efficient Screening Platform

Relying on advanced experimental equipment and high-throughput screening technology, we are able to quickly find the most suitable catalyst and ligand combinations for clients from a large number of options.

Advanced Catalyst and Ligand Library

Our library of ligands and catalysts is extensive and covers multiple derivatives including Pd, Cu, Ni, and other metal catalysts, as well as phosphines, azetidines, carbene, and other ligands, fulfilling the requirements of virtually all reactions.

Advanced Instrumentation

We possess advanced instruments such as GC, HPLC, NMR, XRD, TEM, etc., which scan in detail the course of reactions and properties of catalysts to provide precise and accurate information.

As a company focused on green chemistry and sustainable synthetic reaction design, CD BioSciences-GreenChemistry is committed to providing clients with efficient, environmentally friendly, and customized C-O coupling reaction solutions. If you are interested in our catalyst and ligand screening services, please feel free to contact us for more information.

Our products and services are for research use only and cannot be used for any clinical purposes.