CD BioSciences-GreenChemistry has a focus on green chemistry and offers specialized eco-friendly screening services for ligands and catalysts for C-N coupling reactions. Our specialists have profound expertise in organic synthesis, with exceptional results in palladium, copper, and electrocatalytic C-N coupling reactions. The broad scope of ligands and catalyst systems we developed enables us to achieve great efficiency and selectivity in C-N bond formation encompassing drug and natural product synthesis as well as materials science.
Forming C-N bonds is relevant in making chemicals valuable for industries like energy, agriculture, pharmaceuticals, and chemicals. Our services related to catalysts and ligand screening are applicable to several essential C-N coupling reactions, as shown in the table below and beyond.
| Reactions | Descriptions |
| Buchwald-Hartwig Coupling Reaction | This reaction is common in the construction of drug complex molecules and is employed for the monoselective coupling of aryl halides to amines for the formation of C-N bonds. |
| Ullmann Coupling Reaction | With copper catalysis, the reaction can be used for the coupling of amines or amides with aryl halides. |
| Chan-Lam Coupling Reaction | Copper-catalyzed coupling of aryl boronic acids with amines can be achieved with mild reaction conditions and good functional group compatibility. |
| Palladium-catalyzed Amination Reaction | This is one of the key strategies for the synthesis of several complex nitrogen molecules using primary or secondary amines with aryl halides and ammonia. |
| Nickel-catalyzed C-N Coupling Reaction | It is suitable for low-cost and efficient C-N bond construction, especially for large-site-resistance or electron-poor substrates. |
| Photocatalytic and Electrocatalytic C-N Coupling Reaction | Utilizing electrocatalytic or photocatalytic methods, the construction of C-N bonds under environmentally acceptable conditions becomes possible. |
High-Throughput Experimentation and Machine Learning Screening Technology
We fully integrated HTE machines with machine learning and AI, enabling us to scan the top catalyst and ligand combinations with ease.
Extensive Catalyst and Ligand Library
We have an extensive library of catalysts and ligands covering a wide range of metals and ligand types, which is capable of meeting different reaction requirements.
Cobalt-catalyzed Photochemical C-N Coupling Technology
Utilising the photochemical C-N coupling reaction system, we developed a new system within cobalt containing Cobalt(II) catalysts.
C-N Coupling Reaction Catalyst Development and Optimization
We design and tailor custom catalysts for different types of C-N coupling reactions to perfectly suit our client's needs. Our catalyst systems utilize an extensive array of metals, such as cobalt, nickel, and palladium, and include photocatalytic and electrocatalytic green catalytic technologies.
We offer catalyst screening services that are based on the principles of green chemistry, giving preference to high toxicity, low energy catalyst selection which are efficient enough to ensure that the reaction is environmentally friendly.
C-N Coupling Reaction Ligand Screening
We employ high-performance experimental technology (HTE) and modern analytical tools to quickly identify the best ligand combinations. Through machine learning and artificial intelligence algorithms, we further optimize ligand selection in order to enhance their reaction efficiency and selectivity.
We conduct turn-key projects where we design ligands tailored to our customers' specific reactions. Our ligand library includes a wide array of ligands that span phosphine ligands, azetidic carbene ligands, and more, catering to the various C-N coupling reaction needs.
Optimization of Reaction Conditions
We also help clients optimize the entire reaction system, including solvent selection, temperature control, and light or electrochemical conditions. Through systematic experiments, we ensure that the reaction is carried out under optimal conditions to improve yield and selectivity.
We set out to incorporate the idea of green chemistry into the entire design of the reaction to achieve minimal, or no, waste, and low energy consumption, and ensure that the procedure is completely sustainable.
CD BioSciences-GreenChemistry specializes in providing clients with catalyst and ligand screening services for C-N coupling reactions. Through advanced catalytic technologies and customized solutions, we help clients optimize reaction conditions and enhance reaction efficiency while reducing environmental impact. If you need to screen the best catalysts and ligands for the C-N coupling reaction, please feel free to contact us.
Our products and services are for research use only and cannot be used for any clinical purposes.