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Metal-catalyzed Cross-coupling Reaction Design Service

The cross-coupling reactions that are catalyzed by metals are one of the important organic synthesis methods that join two different organic molecules, which are usually organohalides and organometallic compounds, via carbon-carbon and carbon-heteroatom bonds with the help of transition metal catalysts like palladium and nickel. Because these reactions are very efficient and selective, they are a valuable tool in both the pharmaceutical and materials science industries.

In a manner that facilitates green innovation in chemistry, CD BioSciences-GreenChemistry delivers design and optimization services for metal cross-coupling that balance environmental sustainability with business efficiency. Our team possesses sufficient knowledge about different metal catalysts and designs specific cross-coupling reaction sequences to reduce unwanted byproducts as well as energy consumption while achieving the desired selectivity and yield.

Common Metal-catalysed Cross-coupling Reactions

Reactions Reactants Catalysts Features
Suzuki Coupling Reaction Aryl or alkenyl boronic acids (esters) with aryl or alkenyl halides. Palladium (Pd) complexes. The reaction is widely used in drug and material synthesis due to mild conditions and a wide range of substrate applicability.
Negishi Coupling Reaction Organozinc reagents with aryl, alkenyl, or alkyl halides. Palladium (Pd) or nickel (Ni) complexes. Due to high selectivity, it is suitable for the synthesis of complex molecules.
Heck Coupling Reaction Olefins with aryl or alkenyl halides. Palladium (Pd) complexes. This reaction is used for the direct construction of carbon-carbon double bonds and is commonly used in the synthesis of functionalized olefins.
Sonogashira Coupling Reaction Terminal alkynes with aryl or alkenyl halides. Co-catalyzed by palladium (Pd) and copper (Cu). Given the efficient construction of carbon-carbon triple bonds, this reaction is suitable for the synthesis of conjugated alkynes.
Buchwald-Hartwig Coupling Reaction Aryl halides with amines or phenols. Palladium (Pd) complexes. This reaction is used to construct carbon-nitrogen and carbon-oxygen bonds and is widely used in the synthesis of drugs and functional materials.
Kumada Coupling Reaction Grignard reagent (organomagnesium reagent) with aryl or alkenyl halides. Nickel (Ni) or Palladium (Pd) complexes. The reaction is highly reactive but sensitive to water and air.

Our Metal-catalyzed Cross-coupling Reaction Design Service

As a company focusing on green chemistry, we are committed to providing our clients with efficient and environmentally friendly design services for metal-catalyzed cross-coupling reactions. The following are our specific services:

Customized Reaction Design

We develop bespoke metal-catalyzed cross-coupling paths that meet the needs of our clients' target molecules. Our scope includes the design of optimized reaction sequences for forming C-C, C-N, and C-O bonds with high efficacy in a responsible and sustainable manner.

Catalyst Screening and Optimisation

We evaluate transition metal catalysts and ligands that work for our clients while optimizing reaction conditions to enhance both selectivity and yield. During this process, we develop green catalyst systems that minimize heavy metal usage and environmental pollution.

Application of Green Catalytic Technology

We combine methods of photocatalysis and electrochemical catalysis as part of green chemistry with classical methods of metal-catalyzed cross-coupling reactions to reduce energy expenditure and pollutant emission during chemical processes.

Substrate Suitability Assessment

We provide substrate suitability assessment services that help our clients select and design appropriate reaction substrates and catalysts. The photo-promoted nickel-catalyzed C(sp2)-C(sp3) cross-coupling reaction is compatible with several radical precursors with excellent functional group tolerance.

By-product Management and Waste Minimisation

Our range of services covers designing chemical reactions that are efficient and economical by producing little to no by-products and waste and offers options for recycling and resource recovery in chemical processes for a circular economy.

Applications

  • Drug Synthesis

Conducting drug research and design involves the application of several metal-catalyzed cross-coupling reactions. An example is the C-N coupling reaction, which is used during the preparation of aromatic amines and their derivatives. We adapt reaction conditions and the choice of catalysts to meet the objectives of making effective and non-threatening drugs for clients engaged in drug discovery activities.

  • Materials Science

Within the field of materials science, high-performance polymers, and other functional materials are created from cross-coupling reactions. A light-activated C(sp2)-C(sp3) cross-coupling reaction catalyzed by nickel produces organic compounds of defined structure, which may serve as useful constituents of plastic electronic devices and other optical materials.

  • Natural Product Synthesis

The synthesis of secondary metabolites is made easy with the use of cross-coupling methods, which have been reported to be efficient and environmentally clean. The development of effective coupling reagents creates opportunities to reduce the number of reaction steps and waste and increase the selectivity and efficiency of the synthesis for the total synthesis of natural products.

CD BioSciences-GreenChemistry stands at the forefront of green chemistry and offers outstanding metal-catalyzed cross-coupling reaction design services to clients. Our chemical expertise, combined with cutting-edge laboratory equipment and innovative research ideas, enables us to produce efficient and cost-effective environmentally friendly catalytic solutions for our clients. We encourage you to contact us whenever you need more details.

Our products and services are for research use only and cannot be used for any clinical purposes.