• An endogenous prostaglandin metabolite with multiple regulatory functions. It inhibits STAT3 activation by covalently binding to Cys259, stabilizes EP2 and EP4 receptors, and suppresses breast cancer cell proliferation. 15-keto-PGE₂ also activates PPAR-γ and promotes fungal growth, offering research applications in cancer biology, inflammation, and host-pathogen interactions.