Natamycin Preservative

In the global food industry, the safety, naturalness, and sustainability of food preservatives has become increasingly important because of growing consumer attention toward health and environmental issues. Synthetic preservatives, for example, are often very effective, but they are heavily regulated and looked down upon by many consumers. Natamycin (CAS No. 7681-93-8) is a polyene macrolide antifungal agent produced via fermentation by Streptomyces natalensis and serves as a methane-free and more precise option for the inhibition of mold and yeast growth in food products. Natamycin's preservation effectiveness is well-known and has safe and recognized regulatory support from the FDA and EFSA. Thus, it is extensively used in the dairy, meat, and bakery industries. We specialize in providing specific solutions through advanced biotechnology systems whereby clients can respond to dynamic changes in the food industry such as quality, safety, and natamycin needs under constant change.

Natamycin usage in agricultural and food industriesFig 1. Natamycin usage in agricultural and food industries (Jong H.K., 2021)

Our focus is to optimize food preservation techniques using natamycin based formulations: fermentation technology, formulation expertise, and regulatory compliance for food industry standards. From strain selection and fermentation process optimization to product formulation and stability testing, regulatory documentation, and velations in governance and policy compliances, we offer full service packages. Enhanced shelf life while maintaining ingredients' integrity as well as compliance with international food safety standards is our primary objective for food manufacturing clients.

Technical Principles

The antifungal activity of natamycin results from its binding to ergosterol, a vital sterol embedded in fungal cell membranes. This binding inhibits critical processes such as membrane integrity disruption, membrane fusion, and transport processes, ultimately causing cell death. Unlike broad-spectrum chemical preservatives, natamycin has a unique selectivity for fungi and yeasts (e.g., Candida, Aspergillus, Penicillium) and does not affect the bacterial flora. Its low Solubility (0.41 g/L at 21 Degrees Celcius) in Water ensures Surface Specific Activity which minimizes migration into food matrices.

Technical Features

  • High Specificity: Targets fungi without disrupting beneficial bacteria.
  • Low Resistance Risk: No reported cases of development of fungal resistance due to its unique binding to ergosterol.
  • Thermal Stability: Retains efficacy even after prolonged exposure to high temperature processing such as baking and pasteurization.
  • Surface Activity: best suited for application to surfaces of objects such as cheese rinds and sausages with little to no penetration.

Technical Classification

Our preservatives based on natamycin are specially designed for various food applications:

  • Aqueous Suspensions: Used for spraying or dipping the surfaces of cheeses and cured meats.
  • Coating Emulsions: Incorporated into edible coatings used for fruits, baked goods and processed meat.
  • Dry applications on spices, flours, and powdered beverages require formulations in a powdered form.
  • With synergistic blends of plant extracts or organic acids, there is enhancement of spectrum and efficacy in combination systems.

Application Areas

  • Dairy Products: Surface treatment of hard and semi-hard cheeses to prevent mold growth.
  • Meat and Poultry: Coating for dry-cured sausages and fermented meats.
  • Bakery and Confectionery: Preservation of bread, cakes, and fillings.
  • Beverages: Control of yeast in dairy-based drinks and fruit juices.
  • Plant-Based Foods: Extending shelf life of vegan cheeses and meat alternatives.

Environmental Benefits

Natamycin aligns with circular economy principles due to its biodegradability and low environmental persistence. As a fermentation-derived product, it reduces reliance on synthetic chemicals, lowering the carbon footprint of food preservation. Its targeted action minimizes dosage requirements, further reducing waste and environmental impact.

Our Services

Our company provides comprehensive solutions to integrate natamycin into food preservation systems:

  • Strain Development: High-yield Streptomyces strains optimized for industrial fermentation.
  • Fermentation Process Design: Scalable bioreactor systems for cost-effective natamycin production.
  • Formulation Development: Customized delivery systems (e.g., nanoemulsions, encapsulation) to enhance stability and application efficiency.
  • Analytical Testing: HPLC, UV-Vis spectroscopy, and microbiological assays to verify purity and potency.

Company Service Advantages

  • Strain Development: High-yield Streptomyces strains optimized for industrial fermentation.
  • Fermentation Process Design: Scalable bioreactor systems for cost-effective natamycin production.
  • Formulation Development: Customized delivery systems (e.g., nanoemulsions, encapsulation) to enhance stability and application efficiency.
  • Analytical Testing: HPLC, UV-Vis spectroscopy, and microbiological assays to verify purity and potency.

Contact Us

As the food sector adopts clean label and environmentally sustainable approaches, they need effective, natural preservatives that work for the long term. Our development services for natamycin preservative development services accompanies clients from concept through commercial viability providing scientifically sound environmentally responsible innovations. With partnership, food manufacturers enhance product shelf-life, attain easy compliance, and active consumer confidence effortless in gaining during a competitive landscape. Please contact us for more information.

How to Place an Order

How to place an order

Reference

  1. Jong H.K.,  Christina C.T., et al. "Antifungal Efficacy of Redox-Active Natamycin against Some Foodborne Fungi—Comparison with Aspergillus fumigatus" Foods 2022, 10(9):2073.

Our products and services are for research use only and cannot be used for any clinical purposes.

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