Nisin Preservative

The exceptional safety and effectiveness of Nisin as a food preservative is well known. Nisin is an antimicrobial peptide produced by Lactococcus lactis, and like all good things, Nisin comes with a few caveats. This amazing peptide is able to biodegrade and conquer one of the greatest foes of food preservation - Gram-positive bacteria, including the dreaded-of-the-dreaded spore-forming Bacillus and Clostridium species. Nisin has received GRAS status from regulatory authorities and is legal in more than 50 countries, so clearly, it aids in fighting against the shedload of synthetic preservatives that are flooding the market and is in demand due to it being clean-label and eco-friendly. We, as a company, are proud to say that we developed Nisin based preservative systems and strive to provide custom solutions for food applications by utilizing state-of-the-art biotechnology.

Fig 1. Active Packaging Containing Nisin for Preservation of Food (Elisabeta E.P., 2022)

Our complete nisin preservative development services start with strain optimization and fermentation, followed by advanced extraction and formulation preserving the entire value chain. Biopreservation is our forte and with decades of experience come innovative technologies like membrane separation, dual-module purification, and precision fermentation that guarantee increased yield, purity, functionality, and value. They also aid in complying with regulatory demands while minimizing costs and ecological damage.

Technical Principles

Nisin exerts antimicrobial activity by destroying the synthesis of bacterial cell walls. Nisin has a charge because it is a peptide. It attaches itself to lipid II, which is a precursor in the construction of peptidoglycan. This leads to pore formation, leakage of important cellular components, and eventually, cell lysis. This method is particularly effective against bacterial spores that are heat resistant and survive the conventional sterilization process. During the germination stage, nisin attacks the spores, inhibiting their outgrowth. This renders them susceptible to mild thermal processing. It does not interfere with the gram-positive bacteria that are useful to the body, gut microbiota, and thus, is harmless.

Technical Features

• High Stability: Nisin retains significant activity under high-temperature processing and acidic conditions.
• Enhanced Solubility: Optimized solubility across a wide pH range for versatile application.
• Eco-Friendly Production: Advanced extraction methods minimize chemical additives and reduce energy consumption.
• Long-Term Efficacy: Purification technologies ensure extended shelf life without potency loss.

Technical Classifications

Nisin development services are categorized into three core areas:

• Fermentation Optimization: High-density fermentation using proprietary strains and nutrient formulations.
• Purification Technologies:
  Ceramic Membrane Filtration: Ensures impurity removal while preserving peptide integrity.
  Ultrafiltration & Dual-Module Systems: Achieve high purity and active content through multi-stage processing.
• Application-Specific Formulations: Customized blends for compatibility in dairy, meat, and plant-based products..

Application Areas

• Dairy Products: Extends shelf life of pasteurized milk, yogurt, and cheese.
• Meat Preservation: Reduces reliance on synthetic additives while maintaining freshness.
• Plant-Based Foods: Enables milder sterilization processes to preserve nutritional quality.
• Ready-to-Eat Meals: Inhibits pathogens in canned and packaged goods.

Environmental Benefits

By replacing synthetic preservatives, Nisin reduces chemical runoff and bioaccumulation risks. Our production processes prioritize low wastewater discharge and energy efficiency, while Nisin's biodegradability ensures no persistent environmental residues.

Our Services

We provide complete solutions regarding nisin preservative development, which are tailored based on the client's specifications:

Strain Screening & Fermentation Design:

• Isolation of high-yield strains and scalable bioreactor protocols.

Downstream Processing:

• Membrane filtration for high-purity extracts.
• Advanced drying and pulverization techniques for optimal solubility.

Application Support:

• Dosage optimization based on product matrices.
• Stability testing under varying pH and thermal conditions.
• Regulatory compliance consulting.

Pilot-Scale Production:

• Bridging R&D and commercialization with scalable trials.

Company Service Advantages

Contact Us

As a leader in biopreservation, our nisin preservative development services combine scientific rigor with sustainable innovation. By harnessing advanced fermentation, purification, and application technologies, we deliver solutions that enhance food safety, extend shelf life, and reduce environmental footprints. Partner with us to transform your preservation strategy with a natural, efficacious, and future-proof alternative to synthetic additives.

How to Place an Order

Our products and services are for research use only and cannot be used for any clinical purposes.