2',3'-Dihydro-2'-hydroxyprotoapigenone

2',3'-Dihydro-2'-hydroxyprotoapigenone, with the CAS number 1365655-88-4, belongs to the class of protoflavonoids—a distinctive subgroup of flavonoids renowned for their unique structural features and biological activities. This naturally occurring compound was first isolated from specific fern species, including Equisetum fluviatile and Phegopteris decursive-pinnata, highlighting its botanical origin in ancient and diverse plant lineages.
Flavonoids as a whole are well-documented for their polyphenolic structures and associated bioactivities, but protoflavonoids like 2',3'-Dihydro-2'-hydroxyprotoapigenone stand out due to their specialized molecular framework, which contributes to their specific biological functions. Notably, this compound is closely related to protoapigenone, another well-studied protoflavonoid, sharing structural similarities while exhibiting distinct chemical and biological properties.
Primarily recognized for its research value, 2',3'-Dihydro-2'-hydroxyprotoapigenone is strictly intended for scientific investigation and is not approved for human consumption or clinical use. Its presence in academic and industrial research settings is supported by citations in top-tier scientific journals such as Nature, Cell, and Science, underscoring its significance in advancing fields like cancer biology and natural product chemistry.

Natural Botanical Origin: Derived from select fern species, ensuring a source that aligns with studies on plant-derived bioactive compounds and their ecological and biological roles.
Defined Chemical Classification: Classified as a protoflavonoid, a subgroup of flavonoids with unique structural characteristics that differentiate it from other common flavonoid types like flavones or flavanols.
Research-Only Designation: Explicitly formulated for laboratory and research applications, with clear delineation from compounds intended for commercial or clinical use.
Supported by Scientific Literature: Backed by citations in high-impact scientific publications, reflecting its recognition and utility in rigorous academic and industrial research projects.
Well-Documented Structural Identity: Possesses a characterized chemical structure, which is foundational for structure-activity relationship (SAR) studies and mechanistic research.

Anticancer Mechanism Research: Used to investigate cytotoxic effects on various cancer cell lines, including studies on cell cycle arrest, apoptosis induction, and the modulation of signaling pathways (e.g., MAPK, JNK).
Structure-Activity Relationship (SAR) Studies: Serves as a key compound in analyzing how structural modifications of protoflavonoids impact biological activity, particularly regarding cytotoxicity and target specificity.
Natural Product Chemistry Research: Aids in the isolation, identification, and characterization of bioactive compounds from ferns and other plant sources, contributing to the discovery of new therapeutic leads.
Cellular and Molecular Biology Experiments: Utilized in in vitro assays to study centrosomal integrity, mitochondrial function, and oxidative stress responses in tumor cells.
Preclinical Drug Discovery: Supports preliminary investigations into the potential of protoflavonoids as chemotherapeutic agents, building on the promising anticancer activity of related compounds like protoapigenone.

In the field of protoflavonoid and anticancer natural product research, several related compounds are of interest to researchers. Protoapigenone, a close structural analog, is widely studied for its potent inhibitory activity against multiple cancer cell lines (e.g., Hep G2, MCF-7, A549) and its ability to induce apoptosis via MAPK activation. Protogenkwanoe, another fern-derived protoflavonoid, shares cytotoxic properties and is often included in comparative studies on flavonoid bioactivity. Additionally, protoapigenin and 4'-O-β-D-glucopyranosyl protoapigenin are relevant compounds, as they contribute to understanding the structural diversity and biological functions of protoflavonoids from fern sources. If you are interested in related products, you can directly contact us for product customization services.