• Aeroplysinin 1 is a bioactive metabolite isolated from marine sponges, exhibiting strong antibiotic effects against Gram-positive bacteria and antiviral activity against HIV-1 (IC₅₀ = 14.6 μM). It also possesses anti-inflammatory, anti-angiogenic, and antitumor properties, and can induce apoptosis in endothelial cells. Its multifunctional activity makes it promising for drug development.