Citicoline (Standard)

Citicoline, with the International Nonproprietary Name (INN) Citicoline, is a naturally occurring endogenous compound that plays a pivotal role in cellular physiology, particularly within the nervous system. It is widely recognized by its synonyms, including cytidine 5'-diphosphocholine and CDP-choline.
Chemically identified by the CAS number 987-78-0, its molecular formula is C₁₄H₂₆N₄O₁₁P₂, with a molecular weight of 488.32. This compound exists inherently in the cells of humans and animals—most notably in organs like the liver and brain—and can also be found in dietary sources such as meat, fish, and animal offals.
At its core, Citicoline acts as a critical intermediate in the biosynthesis of phosphatidylcholine, a major component of cell membranes that is essential for maintaining structural integrity and fluidity. Beyond membrane formation, it serves as a precursor for key neurotransmitters, making it integral to neuronal communication and brain function.
The scientific and clinical interest in Citicoline has grown steadily due to its multifaceted roles in neuroprotection and cognitive support. Early research focused on its role in membrane repair, while modern studies have expanded to explore its potential in addressing age-related cognitive decline, neurological injuries, and even visual health. Today, it is a widely studied compound in pharmaceuticals, nutraceuticals, and research, valued for its well-documented mechanisms of action and safety profile.

Dual Neuroprotective & Neuroregenerative Action: Works through multiple pathways—enhancing phosphatidylcholine synthesis to repair neuronal membranes, reducing oxidative stress, and inhibiting neuronal apoptosis—simultaneously protecting cells and supporting recovery.
Proven Cognitive Support: Stimulates the production of acetylcholine, a neurotransmitter critical for memory and learning, and has been shown to improve attention, focus, and memory recall in both healthy adults and populations with age-related decline.
Versatile Compatibility: Soluble in common laboratory solvents like DMSO and stable under ambient shipping conditions (non-hazardous classification), making it suitable for diverse applications from in vitro research to supplement formulation.
Clinically Validated Efficacy: Supported by numerous clinical studies, including trials showing improved Mini-Mental State Examination (MMSE) scores in dementia patients and enhanced brain energy metabolism (up by 14% in healthy adults).

Cognitive Health Supplements: Formulated into nutraceuticals targeting memory enhancement, mental clarity, and focus—particularly for adults seeking to mitigate age-related cognitive decline or support daily cognitive performance.
Neurological Research & Therapeutics: Used in preclinical and clinical studies exploring treatments for stroke recovery, traumatic brain injuries, and neurodegenerative disorders (e.g., Alzheimer’s, Parkinson’s disease) due to its neuroprotective properties.
Visual Health Formulations: Investigated for applications in ophthalmology, as research indicates it slows retinal nerve breakdown and improves visual brain activity, supporting potential use in conditions like glaucoma.

In the field of cognitive health and neurological support, complementary products to Citicoline include other nootropic compounds and neuroprotective agents such as phosphatidylserine (a cell membrane phospholipid supporting memory), acetyl-L-carnitine (a mitochondrial energy booster for brain function), huperzine A (an acetylcholinesterase inhibitor aiding neurotransmitter retention), and omega-3 fatty acids (supporting neuronal membrane health). These products align with Citicoline’s research focus on cognitive enhancement, neuroprotection, and age-related brain health. If you are interested in related products, you can directly contact us or inquire about customized product services.