Cyclo(Tyr-Gly)

Cyclo(Tyr-Gly), scientifically known as (3S)-3-((4-HYDROXYPHENYL)METHYL)-2,5-PIPERAZINEDIONE with CAS number 5625-49-0, belongs to the class of cyclic dipeptides—a group of compounds characterized by their compact 2,5-piperazinedione core structure. These molecules, either naturally occurring or synthetically derived, have garnered significant attention in biomolecular science due to their diverse biological activities and structural stability.
Cyclo(Tyr-Gly) has several recognized English aliases, including CYCLO(-GLY-TYR), CYCLO(GLY-L-TYR), and 3-((4-hydroxyphenyl)methyl)-2,5-Piperazinedione. Its chemical formula is C₁₁H₁₂N₂O₃, corresponding to a molecular weight of 220.22 g/mol.
Naturally, cyclic dipeptides like Cyclo(Tyr-Gly) can be isolated from microbial fermentation processes, while they are also commonly synthesized through chemical methods for laboratory and research applications. The compound’s structure, featuring a hydroxyphenyl group attached to the piperazinedione ring, endows it with unique interactions with biological targets, laying the foundation for its potential bioactive properties.

High Purity for Reliable Research: Available with purities reaching HPLC ≥ 98% (and even up to 99.70% for closely related analogs), ensuring minimal impurities that could interfere with experimental results.
Structural Stability: As a cyclic dipeptide, its ring structure confers greater stability compared to linear peptides, reducing degradation risks during storage and experimental procedures.
Well-Characterized Properties: Comprehensive data on its physical and chemical parameters (such as solubility, melting point, and molecular characteristics) is readily available, facilitating experimental design and protocol optimization.
Flexible Availability: Offered in multiple practical packaging options (e.g., 10mg solid or 1mL*10mM solutions in DMSO), catering to diverse research scale needs from small-volume assays to larger experiments.
Proven Bioactive Potential: Its documented ability to interact with biological targets (receptors or enzymes) and modulate cellular pathways provides a valuable foundation for therapeutic and biochemical research.

Neuroscience Research: Investigated as a potential neuroprotective agent, with studies focusing on its ability to support neural cell health and its potential relevance in developing treatments for neurological disorders.
Antioxidant Studies: Utilized to explore antioxidant activity, particularly its role in counteracting oxidative stress and related pathological pathways in cellular and biochemical models.
Drug Discovery & Development: Serves as a lead compound in pharmacology research, aiding in the identification and optimization of novel therapeutic agents targeting specific biological pathways.
Biochemical Investigations: Employed as a molecular tool to study peptide-protein interactions, enzyme modulation, and cellular signaling pathways, enhancing understanding of fundamental biological processes.
Synthetic Chemistry Research: Used as a model compound in developing and optimizing synthetic methodologies for cyclic dipeptides, supporting the production of other bioactive cyclic peptide derivatives.

Customers interested in Cyclo(Tyr-Gly) may also find value in other cyclic dipeptides within the same research domain, such as Cyclo(Gly-Tyr) (CAS 5845-66-9)—a structural isomer with similar molecular weight and 2,5-piperazinedione core, widely studied for its bioactive properties. Additionally, cyclic dipeptides like Cyclo(Phe-Gly) and Cyclo(Tyr-Tyr) are relevant, as they share the cyclic dipeptide scaffold and are investigated for roles in neuroscience, antioxidant research, and drug discovery. Linear peptide precursors such as H-Gly-Tyr-OH, which serve as building blocks for synthesizing Cyclo(Tyr-Gly) and related cyclic compounds, are also of interest for synthetic chemistry applications. If you are interested in related products, you can directly contact us or inquire about product customization services.