Epimedonin B

Epimedonin B is a naturally occurring flavonoid compound primarily isolated from plants of the Epimedium genus (commonly known as horny goat weed), a group of perennial herbs widely distributed across East Asia, including China, Japan, and Korea. For centuries, Epimedium species have been valued in traditional Chinese medicine (TCM) for their purported health-promoting properties, with historical records dating back to the Han Dynasty (206 BCE–220 CE) in medical texts such as Shennong Ben Cao Jing (Shennong's Herbal Classic).
As a key bioactive constituent of Epimedium, Epimedonin B belongs to the flavonol subclass of flavonoids, characterized by a 3-hydroxyflavone backbone. Its discovery and structural elucidation in modern times have been driven by growing interest in the therapeutic potential of natural products, with early research focusing on isolating and identifying compounds responsible for the traditional effects of Epimedium extracts.
Key aspects of its background include:
Natural abundance: Concentrated in the leaves and stems of Epimedium species, with varying levels depending on the plant variety, growth environment (e.g., altitude, soil composition), and harvesting time.
Structural uniqueness: Features a distinct chemical structure with hydroxyl groups and glycosidic moieties that contribute to its biological activity and solubility profiles.
Research evolution: Over the past few decades, Epimedonin B has emerged as a subject of intensive scientific investigation, transitioning from traditional use to modern pharmacological and biomedical research due to its diverse biological effects.
Unlike some widely studied flavonoids, Epimedonin B does not have widely recognized English aliases, but it is occasionally referenced in scientific literature by its systematic chemical name: 3,5,7-trihydroxy-2-(4-methoxyphenyl)-6-(3-methylbut-2-enyl)chromen-4-one (or analogous IUPAC designations) for precision in research contexts.

High Purity Profile: Manufactured through advanced extraction and purification techniques (e.g., column chromatography, HPLC refinement) to achieve purity levels of ≥98%, ensuring minimal contamination from other plant metabolites and consistent performance in experimental or industrial applications.
Natural Origin Authenticity: Sourced exclusively from sustainably cultivated Epimedium plants, adhering to eco-friendly harvesting practices to preserve botanical integrity and reduce environmental impact.
Stable Chemical Properties: Maintains structural stability under recommended storage conditions (cool, dry, and protected from light), with a long shelf life that supports long-term research projects or industrial inventory management.
Excellent Solubility: Exhibits favorable solubility in common organic solvents (e.g., ethanol, methanol, DMSO) and moderate solubility in aqueous solutions, facilitating versatile use in in vitro, in vivo, and formulation studies.
Rigorous Quality Control: Each batch undergoes comprehensive testing, including HPLC for purity quantification, NMR and MS for structural confirmation, and microbial limit testing, to meet international quality standards for research and commercial use.

Biomedical Research: Widely used in preclinical studies to investigate its potential therapeutic effects, including neuroprotection (e.g., in Alzheimer’s and Parkinson’s disease models), cardioprotection, anti-inflammatory activity (targeting conditions like arthritis), and antioxidant defense against oxidative stress-related disorders.
Pharmaceutical Development: Serves as a lead compound for the synthesis of novel drug candidates, with modifications to its chemical structure aimed at enhancing bioavailability, potency, or target specificity.
Nutraceutical and Cosmetic Formulations: Incorporated into dietary supplements and skincare products for its antioxidant properties, which may support skin health, reduce oxidative damage, and promote overall wellness.
Agricultural Research: Explored for its potential as a natural plant growth regulator or biopesticide, leveraging its plant-derived origin to develop eco-friendly agricultural solutions.
Chemical Biology: Used as a tool compound to study flavonoid signaling pathways, enzyme inhibition, and molecular interactions in biological systems, advancing our understanding of natural product chemistry.

Researchers and industry professionals interested in Epimedonin B may also explore other bioactive flavonoids and natural compounds from the Epimedium genus or related botanical families, including Epimedium flavonoids such as icariin, icariside II, baohuoside I, and sagittatoside A—all of which share similar structural scaffolds and biological activities. Additionally, complementary compounds like quercetin, kaempferol, myricetin, and resveratrol (from diverse plant sources) are of interest for their overlapping pharmacological effects, such as antioxidant and anti-inflammatory properties, making them valuable for combination studies or multi-component formulations. If you are interested in related products, you can directly contact us for product customization services.