Latrunculin A • A G-actin polymerization inhibitor derived from the Red Sea sponge Latrunculia magnifica. Latrunculin A binds to actin monomers with Kd values of 0.1 μM (ATP-actin), 0.4 μM (ADP-Pi-actin), 4.7 μM (ADP-actin), and 0.19 μM (G-actin), effectively blocking actin polymerization. It exhibits strong anti-metastatic effects and inhibits cell migration, making it a valuable tool in cancer and cytoskeletal research.
| CAS No. | 76343-93-6 |
| Purity | ≥98.0% |
| Synonyms | LAT-A |
| Molecular Weight | 421.55 |
| Formula | C22H31NO5S |
| Appearance | Liquid |
| Color | Colorless to light yellow |
| SMILES | O=C1SC[C@@H]([C@]2(O)O[C@]3([H])CC[C@H](C)/C=C\C=C\CC/C(C)=C\C(O[C@@](C3)([H])C2)=O)N1 |
| Intended Use | For research use only. |
| Shipping | Room temperature |
| Storage | Solution: -20°C, 2 years |
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