Lepadin E • Lepadin E, a potent ferroptosis inducer, induces iron-dependent cell death through the classical p53-SLC7A11-GPX4 pathway. It promotes p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased reactive oxygen species (ROS) and lipid peroxide production. Additionally, Lepadin E upregulates ACSL4 expression, resulting in significant cell death and exhibiting a strong antitumor effect.
| CAS No. | 444914-19-6 |
| Molecular Weight | 421.66 |
| Formula | C26H47NO3 |
| SMILES | CCC[C@H](CCCC[C@@H](CCC[C@@]12[H])[C@]2([H])C[C@H]([C@@H](N1)C)OC(/C=C/CCCCC)=O)O |
| Intended Use | For research use only. |
| Shipping | Room temperature |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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