Manzamine A hydrochloride • An orally bioavailable marine β-carboline alkaloid with broad bioactivity. Manzamine A hydrochloride specifically inhibits GSK-3β and CDK5 with IC₅₀ values of 10.2 μM and 1.5 μM, respectively. It targets vacuolar ATPases and disrupts autophagy in pancreatic cancer cells. Additionally, it displays potent antimalarial, anticancer, and antiviral (HSV-1) activities, making it a promising lead compound in multiple therapeutic areas.
| CAS No. | 104264-80-4 |
| Purity | 99.66% |
| Synonyms | Keramamine A hydrochloride |
| Molecular Weight | 585.22 |
| Formula | C36H45ClN4O |
| Appearance | Solid |
| Color | Light yellow to brown |
| SMILES | O[C@]1(CC/C=C\CCCC2)[C@@]3([H])[C@@](C[C@@]4([H])N3CCCC/C=C\4)(C[N@@]2CC5)[C@]5([H])C(C6=C(NC7=CC=CC=C87)C8=CC=N6)=C1.Cl |
| Intended Use | For research use only. |
| Shipping | Room temperature |
| Storage |
4°C, sealed storage, away from moisture and light In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
CD BioSciences is a well-known professional company in the industry. We provide a wide range of bio-environmental products, including bio-based materials, biomass fuels, green building materials, bio-environmental enzymes, bio-environmental microorganisms, etc. Please feel free to explore.
Our products and services are for research use only and cannot be used for any clinical purposes.
