Marizomib • A second-generation, irreversible, brain-penetrant pan-proteasome inhibitor. Marizomib targets the 20S proteasome, inhibiting CT-L (β5), caspase-like (C-L, β1), and trypsin-like (T-L, β2) activities with IC₅₀ values of 3.5 nM, 28 nM, and 430 nM, respectively. Widely used in oncology and neuro-oncology research.
| CAS No. | 437742-34-2 |
| Purity | 99.13% |
| Synonyms | Salinosporamide A; NPI-0052 |
| Molecular Weight | 313.78 |
| Formula | C15H20ClNO4 |
| Appearance | Solid |
| Color | Off-white to pink |
| SMILES | O=C([C@H](CCCl)[C@]1(C)O2)N[C@@]1([C@H]([C@@H]3C=CCCC3)O)C2=O |
| Intended Use | For research use only. |
| Shipping | Room temperature |
| Storage |
Powder: -20°C, 3 years; 4°C, 2 years In solvent: -80°C, 2 years; -20°C, 1 year |
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