Okadaic Acid • Okadaic Acid, a marine-derived toxin, functions as a potent inhibitor of serine/threonine protein phosphatases. It shows high affinity for PP2A (IC₅₀ = 0.1–0.3 nM), and also inhibits PP1 (IC₅₀ = 15–50 nM), PP3 (IC₅₀ = 3.7–4 nM), PP4 (IC₅₀ = 0.1 nM), and PP5 (IC₅₀ = 3.5 nM), but does not inhibit PP2C. By blocking these phosphatases, okadaic acid enhances protein phosphorylation and acts as a tumor promoter, notably inducing tau protein hyperphosphorylation.
| CAS No. | 78111-17-8 |
| Purity | 99.19% |
| Molecular Weight | 805.00 |
| Formula | C44H68O13 |
| Appearance | Liquid |
| Color | Colorless to light yellow |
| SMILES | O[C@H](CC[C@@H](C[C@@](C)(O)C(O)=O)O1)[C@@]1(C=C(C)C2)O[C@]2([H])[C@H](C)/C=C/[C@@H]3O[C@@]4(O[C@]([C@@H]5O)([H])[C@@](O[C@@]([C@@H](O)C[C@@H]([C@@]6([H])O[C@@]7(CCCCO7)CC[C@H]6C)C)([H])C5=C)([H])CC4)CC3 |
| Intended Use | For research use only. |
| Shipping | Room temperature |
| Storage | Solution: -20°C, 2 years |
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