Plitidepsin • A marine-derived cyclic peptide with potent anticancer activity by targeting eEF1A2 (Kd = 80 nM). Plitidepsin also exhibits antiviral activity, notably against SARS-CoV-2 with an IC₉₀ of 0.88 nM. It is primarily used in studies related to multiple myeloma, advanced solid tumors, and emerging viral diseases including COVID-19.
| CAS No. | 137219-37-5 |
| Purity | 99.99% |
| Synonyms | Aplidine; PM90001 |
| Molecular Weight | 1110.34 |
| Formula | C57H87N7O15 |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C([C@@H](NC([C@H](C([C@@H](OC(C[C@@H]1O)=O)C(C)C)=O)C)=O)CC(C)C)N(CCC2)[C@]2([H])C(N([C@H](C(O[C@@H]([C@@H](C(N[C@]1([H])[C@@H](C)CC)=O)NC([C@@H](CC(C)C)N(C)C([C@H](CCC3)N3C(C(C)=O)=O)=O)=O)C)=O)CC(C=C4)=CC=C4OC)C)=O |
| Intended Use | For research use only. |
| Shipping | Room temperature |
| Storage |
Sealed storage, away from moisture and light, under nitrogen Powder: -80°C, 2 years; -20°C, 1 year In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
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