Ultrafiltration membrane, MWCO 2 kDa

Ultrafiltration (UF) membranes represent a critical class of separation technologies widely employed across scientific research and industrial processes, enabling precise isolation of molecules based on their molecular weight. At the core of an ultrafiltration membrane’s functionality is its Molecular Weight Cut-Off (MWCO), defined as the lowest molecular weight of a solute (typically in Daltons) for which 90% of the substance is retained by the membrane. This standardized performance metric ensures consistency in separation outcomes, making MWCO a primary consideration for researchers and manufacturers when selecting membranes for target applications.
Our 2 kDa MWCO ultrafiltration membrane falls into the low MWCO category, designed to retain small biomolecules and macromolecular fragments while allowing smaller solutes to permeate. This specific cut-off is engineered to address the growing demand for precise separation in fields like biopharmaceuticals and analytical chemistry, where even minor differences in molecular size can impact experimental results or product purity.
Commonly constructed from high-performance materials such as regenerated cellulose (RC) or polyethersulfone (PES) , 2 kDa ultrafiltration membranes leverage advanced fabrication techniques—including phase inversion and copolymer modification—to achieve controlled pore structures. These materials are selected for their ability to balance selectivity with operational durability, ensuring reliable performance across repeated use cycles.
In recent years, innovations in membrane technology have further enhanced the utility of 2 kDa MWCO membranes. For example, modifications with hydrophilic or antimicrobial additives have improved resistance to fouling and microbial growth , addressing longstanding challenges in maintaining flux stability and sample integrity. Such advancements have solidified the role of 2 kDa ultrafiltration membranes as indispensable tools in both laboratory-scale sample preparation and pilot-scale bioprocessing.

Store at a low temperature and in a dry environment.

Application in food industry: Ultrafiltration membrane is used in the concentration and clarification treatment of fruit beverages.
Industrial wastewater treatment: In industrial wastewater treatment, ultrafiltration membranes can effectively remove macromolecular organics and impurities and reduce environmental pollution.
Surface water treatment: Purify algae and particulate impurities in lakes, rivers and other water to make it more suitable for drinking or industrial use.
Electronic industry: Used for pure water preparation and wastewater recycling in electronic and semiconductor manufacturing processes.
Textile industry: For treatment and recycling of textile dye wastewater.

Precise MWCO Calibration: Rigorously manufactured to maintain a 2 kDa molecular weight cut-off, ensuring 90% retention of target solutes within this molecular range for consistent separation outcomes.
Broad Material Compatibility: Available in premium formulations such as regenerated cellulose (RC) and polyethersulfone (PES), tailored to suit diverse application needs—from protein-sensitive experiments to chemical-resistant industrial processes.
Extended pH Stability: Engineered to perform reliably across a wide pH range (typically 1.0–13.0 for RC variants), accommodating acidic and alkaline sample matrices without compromising membrane structure.
Low Extractable Content: Undergoes stringent purification to minimize leachable substances, ensuring compatibility with sensitive applications like biopharmaceutical purification and endotoxin-free sample processing.
Versatile Format Compatibility: Designed to integrate seamlessly with common ultrafiltration equipment, including stirred cells, tangential flow filtration (TFF) cassettes, and centrifugal devices.
Enhanced Hydrophilicity: Surface-modified to promote water wettability, reducing protein adsorption and minimizing fouling to maintain consistent flux over time.

Biopharmaceutical Purification: Used for concentration and buffer exchange of small proteins, peptides, and oligonucleotides, critical steps in monoclonal antibody (mAb) and recombinant protein manufacturing.
Analytical Sample Preparation: Prepares samples for downstream analysis (e.g., HPLC, mass spectrometry) by removing low-molecular-weight contaminants or desalting protein solutions.
Cell and Gene Therapy: Enables purification of viral vectors, exosomes, and lipid nanoparticles (LNPs) by retaining target biomolecules while eliminating smaller impurities.
Environmental Monitoring: Isolates macromolecular organic matter from water or soil samples, supporting analysis of pollutants and microbial metabolites.
Food and Beverage Testing: Concentrates bioactive peptides or enzymes from food extracts while removing salts and small-molecule additives.
Academic Research: Facilitates studies in biochemistry and molecular biology, such as protein-protein interaction assays and metabolite separation.

Customers interested in 2 kDa MWCO ultrafiltration membranes often seek complementary products for comprehensive separation workflows, including ultrafiltration membrane discs with higher MWCOs (5 kDa, 10 kDa, 30 kDa) for gradient molecular weight separation, tangential flow filtration (TFF) cassettes optimized for pilot-scale processing, and centrifugal ultrafiltration devices for small-volume sample concentration. Additionally, regenerated cellulose (RC) and polyethersulfone (PES) membrane variants with identical 2 kDa MWCO but different physical formats (e.g., hollow fibers, flat sheets) cater to specific equipment requirements. Other relevant products include membrane cleaning solutions designed to maintain flux and extend membrane life, and sterile filtration accessories for aseptic sample processing. If you are interested in related products, you can directly contact us or use our product customization service.