Bryostatin 1 • A CNS-permeable, natural macrolide derived from the marine bryozoan Bugula neritina, acting as a potent modulator of protein kinase C (PKC). Bryostatin 1 binds to Munc13-1 with Kis of 8.07 nM (C1 domain) and 0.45 nM (full-length protein). It exhibits anti-cancer, neuroprotective, anti-inflammatory, and anti-HIV-1 activities, making it valuable in oncology, neurodegeneration, and viral infection research.
| CAS No. | 83314-01-6 |
| Purity | 99.70% |
| Molecular Weight | 905.03 |
| Formula | C47H68O17 |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O[C@]12[C@H](/C(C[C@](C[C@](OC(C[C@@H](C[C@@]3([H])O[C@](O)(C(C)([C@@H](OC(C)=O)C3)C)C[C@@](C/4)([H])O[C@@](CC4=C/C(OC)=O)([H])/C=C/C2(C)C)O)=O)([H])[C@H](O)C)([H])O1)=C/C(OC)=O)OC(/C=C/C=C/CCC)=O |
| Intended Use | For research use only. |
| Shipping | Room temperature |
| Storage |
Powder: -20°C, 3 years In solvent: -80°C, 6 months; -20°C, 1 month |
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