Calycosin 7-O-xylosylglucoside

Calycosin 7-O-xylosylglucoside is a naturally occurring isoflavone glycoside, primarily isolated from plants of the Fabaceae family—with Astragalus membranaceus (a well-known traditional Chinese medicinal herb) being its most prominent natural source. This compound belongs to the broader class of flavonoid derivatives, characterized by a specific chemical structure: it consists of a calycosin aglycone (the active isoflavone core) linked to a disaccharide chain composed of one xylose and one glucose moiety at the 7-O position.
In recent decades, Calycosin 7-O-xylosylglucoside has gained significant attention in the fields of pharmaceuticals, cosmetics, and functional foods due to its close structural association with calycosin (its aglycone form) and other bioactive isoflavones. Unlike free calycosin, the xylosylglucoside modification (a type of glycosylation) enhances the compound’s water solubility—a critical property for formulating liquid-based products such as oral supplements or skincare serums. This glycosylation also contributes to improved stability under mild processing conditions (e.g., low-temperature extraction, moderate pH ranges), reducing the risk of degradation and preserving its biological activity.

Natural Plant Origin: Derived exclusively from renewable plant sources (primarily Astragalus membranaceus), aligning with global demands for sustainable, eco-friendly ingredients and avoiding synthetic chemical synthesis.
Enhanced Solubility: The 7-O-xylosylglucoside disaccharide chain significantly improves water solubility compared to its aglycone (calycosin) and monoglycoside analogs, enabling seamless integration into aqueous formulations (e.g., liquid supplements, water-based skincare products).
Structural Stability: The glycoside moiety protects the calycosin core from oxidative degradation and thermal instability under standard storage and processing conditions (e.g., room temperature, pH 5–7), extending the product’s shelf life.
Targeted Bioactive Potential: Retains the structural features of calycosin (a well-studied bioactive isoflavone) while modifying its pharmacokinetic properties (e.g., absorption rate in biological systems), making it suitable for applications requiring controlled bioavailability.
High Purity Availability: Produced via advanced extraction and purification techniques (e.g., column chromatography, HPLC), ensuring high purity grades (typically ≥95% as verified by analytical methods like NMR and LC-MS) to meet strict industry standards for pharmaceuticals and cosmetics.

Pharmaceutical and Nutraceutical Industry: Used as an active ingredient or raw material in herbal supplements, traditional medicine formulations, and potential pharmaceutical candidates. It leverages its structural similarity to bioactive isoflavones to support products targeting general wellness, immune function, and metabolic health (based on research into Astragalus-derived compounds).
Cosmetic and Skincare Industry: Incorporated into anti-aging, moisturizing, and soothing skincare products (e.g., serums, creams, masks). Its antioxidant potential (linked to flavonoid structures) and water solubility make it effective for addressing oxidative stress-related skin concerns (e.g., fine lines, dullness) and ensuring even distribution in formulations.
Functional Food and Beverage Industry: Added to functional drinks, fortified snacks, and dietary supplements as a natural bioactive ingredient. Its clean-label profile and compatibility with aqueous beverages (e.g., herbal teas, wellness shots) appeal to consumers seeking nutrient-dense, plant-based food options.
Biological Research: Utilized as a reference standard or research tool in botanical chemistry, pharmacology, and metabolomics studies. It supports investigations into flavonoid glycosylation mechanisms, structure-activity relationships (SAR) of isoflavones, and the bioactivity of Astragalus-derived compounds.

Customers interested in Calycosin 7-O-xylosylglucoside may also explore other plant-derived flavonoid glycosides and isoflavone derivatives, as they share similar applications in pharmaceuticals, cosmetics, and functional foods. Key related products include Calycosin (the aglycone of Calycosin 7-O-xylosylglucoside), Formononetin 7-O-glucoside (another isoflavone glycoside from Astragalus membranaceus), Genistin (a soy-derived isoflavone glycoside), Daidzin (another soy-based isoflavone glycoside with similar solubility features), and Rutin (a flavonol glycoside widely used in cosmetics and supplements for its antioxidant properties). These products overlap in their focus on natural bioactivity, solubility, and sustainable sourcing, making them relevant for customers developing multi-ingredient formulations or expanding their plant-derived ingredient portfolios. If you are interested in related products, you can contact us directly or request product customization services.