Dehydrojuncuenin B

Dehydrojuncuenin B is a naturally occurring phenanthrenoid compound that belongs to the phenol chemical family, with its unique identity defined by the CAS number 1161681-28-2.
This compound was first isolated from the underground parts of Juncus setchuensis Buchen. ex Diels, a plant species belonging to the Juncaceae family. Subsequent research has also identified it in the aerial parts of Juncus setchuensis alongside other phenanthrenes such as effusol, juncusol, and juncuenin D, as well as in the roots of Juncus inflexus. Its discovery emerged from broader studies on bioactive natural products from Juncus plants, which have long been of interest to researchers for their diverse phytochemical compositions and potential biological functions.
In the scientific community, Dehydrojuncuenin B has gained attention due to its documented biological activities, which have been validated through in vitro experiments. Early research focused on its isolation and structural elucidation using techniques like MS and NMR spectroscopy, laying the foundation for subsequent investigations into its functional properties. Today, it is recognized as a valuable tool compound in various fields of biological and pharmaceutical research.

Research Relevance: Aligns with key research priorities in inflammation, infectious diseases, and natural product pharmacology, making it a targeted tool for studies on chronic inflammatory disorders and antibiotic-resistant bacterial infections.
Validated Efficacy: Its biological effects are backed by quantitative data (e.g., specific IC₅₀ values for anti-inflammatory activity and MIC ranges for antimicrobial effects), reducing uncertainty in experimental outcomes.
Compatibility with Experimental Models: Has demonstrated activity in common cell lines such as RAW264.7 macrophages, enabling easy integration into existing in vitro research workflows.
Natural Product Advantage: As a plant-derived compound, it offers an alternative to synthetic molecules for studies exploring natural product-based therapeutics, a growing area of pharmaceutical research.

Anti-Inflammatory Research: Used to investigate the molecular mechanisms of inflammation, particularly in studying the inhibition of nitric oxide production and inducible nitric oxide synthase (iNOS) activity, which are key pathways in chronic inflammatory conditions.
Antimicrobial Studies: Employed in research on antibiotic resistance, specifically in experiments targeting MRSA strains, to explore its potential as a lead compound for new antimicrobial agents.
Natural Product Pharmacology: Serves as a reference compound in the isolation and characterization of other phenanthrenoid compounds from Juncus plants, aiding in the identification of structure-activity relationships.
Drug Discovery Initiatives: Evaluated for its potential as a lead molecule in developing therapeutics for inflammatory diseases and drug-resistant bacterial infections, leveraging its proven in vitro activity.
Cellular Signaling Pathway Analysis: Utilized to study interactions with cellular targets and modulation of downstream signaling pathways related to inflammation and microbial pathogenesis.

Researchers interested in Dehydrojuncuenin B often explore other phenanthrenoid compounds from the Juncaceae family, as they share similar chemical backbones and biological relevance. Key related products include effusol, dehydroeffusol, juncusol, dehydrojuncusol, and juncuenins A, B, and D. These compounds exhibit overlapping and complementary activities—for example, dehydrojuncusol shows anti-inflammatory, antioxidant, and anti-Hepatitis C virus properties, while juncuenin D induces caspase-3-mediated cytotoxicity. Together, they form a toolkit for studying the diverse biological functions of phenanthrenes in inflammation, infectious diseases, and cellular signaling. If you are interested in related products, you can directly contact us for product customization services.