Dihydrobonducellin

Dihydrobonducellin, identified by its CAS number 103680-87-1 and CB number CB43037238, is a naturally derived homoisoflavonoid with significant biological research value. Belonging to the flavonoid compound class, it possesses a distinct molecular structure defined by the formula C₁₇H₁₆O₄ and a molecular weight of 284.31.
This compound is primarily isolated from the herbs of Caesalpinia decapetala, a plant species recognized for its rich phytochemical content. While some homoisoflavonoids are sourced from other botanical families, dihydrobonducellin’s association with Caesalpinia decapetala contributes to its unique bioactive profile. In its physical form, dihydrobonducellin appears as crystals, a characteristic that aids in its purification and identification in laboratory settings.
First documented for its biological activity in scientific research, dihydrobonducellin has gained attention for its role as an immunomodulator—a property that positions it as a key subject in pharmacological and biotechnology studies. Early research identified its ability to interact with specific cellular pathways, sparking further exploration into its potential therapeutic applications and mechanisms of action.

Classified as a homoisoflavonoid, it exhibits structural characteristics that distinguish it from conventional flavonoids, supporting unique interactions with biological targets.
Boasts well-defined chemical properties, including a melting point of 132-134 °C and a predicted density of 1.266 ± 0.06 g/cm³, enabling consistent experimental replication.
Demonstrates good solubility in common laboratory solvents such as DMSO, methanol, ethanol, and pyridine, facilitating easy preparation of experimental solutions.
Maintains stability for at least 2 years when stored under recommended conditions (typically -20 °C), ensuring long-term usability for research projects.
Features a predicted pKa value of 7.73 ± 0.40, which influences its bioavailability and interaction with cellular environments at physiological pH levels.

Immunology Research: Serves as a tool to study immune response regulation, particularly in investigating the role of IL-2 and IFN-γ in autoimmune diseases and inflammatory disorders. Researchers use it to modulate PBMC cell activity and analyze downstream signaling pathways involved in immune function.
Pharmacological Screening: Acts as a lead compound in drug development for conditions linked to dysregulated immunity or chronic inflammation, leveraging its ability to target key pro-inflammatory cytokines.
Biochemical Mechanism Studies: Used to elucidate the interactions between homoisoflavonoids and cellular receptors, contributing to a deeper understanding of flavonoid biology and structure-activity relationships.
Oxidative Stress Research: Explored for potential antioxidant effects, as part of broader studies into how homoisoflavonoids mitigate oxidative damage in biological systems.

In the field of homoisoflavonoid and immunomodulatory research, several complementary compounds align with the interests of researchers working with dihydrobonducellin. These include bonducellin (the structural analog of dihydrobonducellin), other homoisoflavonoids like curcuminoids, and cytokine-modulating agents such as IL-2 inhibitors and IFN-γ antagonists. Additionally, plant-derived flavonoids with anti-inflammatory properties, such as quercetin and luteolin, are frequently sought after for comparative studies on bioactivity and mechanism of action. If you are interested in related products, you can directly contact us or inquire about product customization services.