Hydroquinidine

Hydroquinidine, identified by its CAS number 1435-55-8 and molecular formula C₂₀H₂₆N₂O₂, is a naturally derived alkaloid and a stereoisomer of hydroquinine, originally isolated from cinchona bark. This compound has a well-documented molecular weight of 326.43 and an exact mass matching this value, with its chemical identity further defined by an InChIKey of LJOQGZACKSYWCH-LHHVK LHASA-N and an EC Number of 215-862-5.
It is known by several synonyms in scientific and industrial contexts, including dihydroquinidine, hydroconchinine, hydroconquine, (9S)-10,11-dihydro-6′-methoxycinchonan-9-ol, and (+)-hydroquinidine. Historically, hydroquinidine was first prepared through the hydrogenation of quinidine, a process documented as early as 1919, and its manufacturing methods have since been refined through industrial patents.
Classified under the cardiovascular system (ATC Code: C) and categorized as a circulatory system drug, hydroquinidine has long been recognized for its biological activity, with early pharmacological studies dating back to the 1970s. Its unique chiral structure—featuring 4 defined stereocenters—makes it distinct from related compounds, contributing to both its biological function and chemical utility.

Cardiovascular Research & Therapeutics: Functions as an antiarrhythmic agent, with formulations studied for the treatment of Brugada syndrome—a genetic disorder linked to ventricular fibrillation and sudden death—including phase 3 clinical trials. It modulates cardiac function by increasing sinus cycle length and prolonging QRS duration and ventricular repolarization.
Asymmetric Chemical Synthesis: Acts as a chiral auxiliary and resolving agent for enantiomeric mixtures, facilitating the separation of chiral compounds by forming diastereomeric complexes. It enhances enantioselectivity in key reactions such as reductions, oxidations, and alkylations.
Pharmaceutical & Fine Chemical Development: Used in the synthesis of enantiomerically pure drug candidates and intermediates, contributing to safer, more effective medications by controlling chirality-related biological activity. Its hydrochloride derivative (CAS 1476-98-8) is also utilized in pharmaceutical formulations.
Analytical & Biochemical Research: Imprinted on microspheres as a pseudo-template molecule for the recognition of cinchona alkaloids, supporting the development of detection methods for related compounds. It is also supplied as a research reagent for studies in lipid biochemistry, oncology, and neuroscience.

Customers interested in Hydroquinidine often seek other cinchona alkaloids and chiral reagents for complementary applications. Key related products include quinidine (the parent compound of hydroquinidine), hydroquinine (its stereoisomer), cinchonine, and cinchonidine—all valuable in asymmetric synthesis and pharmaceutical research. Additionally, chiral catalysts like quinine-derived ligands and enantiomeric resolving agents such as tartaric acid derivatives are frequently paired with hydroquinidine for stereoselective reactions. For cardiovascular research, related antiarrhythmic agents like disopyramide and procainamide are common counterparts. If you are interested in related products, you can directly contact us for product customization services.