Psammaplin A • Psammaplin A is a marine-derived natural product that functions as a potent dual inhibitor of histone deacetylases (HDACs) and DNA methyltransferases. It exhibits high selectivity for HDAC1, with an IC₅₀ of 0.9 nM. Psammaplin A also demonstrates antimicrobial activity against Gram-positive bacteria and inhibits both DNA synthesis and DNA gyrase activity. It possesses notable antitumor potential.
| CAS No. | 110659-91-1 |
| Molecular Weight | 664.39 |
| Formula | C22H24Br2N4O6S2 |
| Appearance | Solid |
| Color | Off-white to yellow |
| SMILES | O=C(NCCSSCCNC(/C(CC1=CC(Br)=C(O)C=C1)=N/O)=O)/C(CC2=CC(Br)=C(O)C=C2)=N/O |
| Intended Use | For research use only. |
| Shipping | Room temperature |
| Storage |
4°C, stored under nitrogen In solvent: -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
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