Pseudostellarin G

Pseudostellarin G is a naturally occurring cyclic octapeptide with significant biological research value, first isolated from the roots of Pseudostellaria heterophylla (Miq.) Pax, a plant renowned for its traditional medicinal applications and diverse pharmacological properties. Its unique chemical structure is defined as cyclo(-Pro-Phe-Ser-Phe-Gly-Pro-Leu-Ala-), consisting of eight amino acid residues linked in a cyclic configuration.
With the CAS number 156525-71-2, this compound has a molecular formula of C₄₂H₅₆N₈O₉ and a molecular weight of 816.94. Beyond its natural occurrence, Pseudostellarin G has also been successfully synthesized in laboratory settings, with its structure rigorously validated through analytical techniques including infrared spectroscopy (IR), nuclear magnetic resonance (NMR), and mass spectrometry.
The discovery of Pseudostellarin G aligns with the growing interest in cyclic peptides as a promising class of bioactive compounds. Over the past two decades, cyclic peptides isolated from plants, marine sponges, and tunicates have gained attention for their unique structural stability and diverse biological activities—attributes that make them potential candidates for therapeutic development. As a member of this family, Pseudostellarin G contributes to ongoing research into peptide-based bioactive molecules and their mechanisms of action.

Well-Characterized Structure: As a cyclic octapeptide, its cyclic configuration confers structural rigidity distinct from linear peptides, a trait validated by multiple spectroscopic methods including IR, NMR, and mass spectral analysis.
Dual Origin Availability: Can be sourced from natural Pseudostellaria heterophylla extracts or produced via standardized chemical synthesis, ensuring consistent supply for diverse research needs.
Documented Bioactivity Traits: Exhibits defined biological properties, most notably tyrosinase inhibition and melanin production suppression, with preliminary screening indicating antimicrobial and pharmacological potential.

Dermatological & Cosmetic Research: Used to study melanin regulation pathways due to its ability to inhibit tyrosinase—an enzyme critical for melanin synthesis—supporting the development of skin-lightening or pigmentation-modulating agents.
Antimicrobial Mechanism Studies: Serves as a probe for investigating peptide-based antimicrobial action, particularly membrane perturbation pathways that differ from classical antibiotics.
Cyclic Peptide Synthesis Validation: Acts as a reference standard for optimizing synthetic protocols of cyclic octapeptides, aiding in the development of efficient coupling and cyclization techniques.
Pharmacological Screening: Integrated into high-throughput assays for evaluating peptide bioactivity, including immunomodulatory potential (building on the immunological traits of its host plant Pseudostellaria heterophylla).
Natural Product Chemistry: Used in comparative analyses of bioactive compounds from Pseudostellaria heterophylla, helping to delineate the contribution of specific peptides to the plant’s traditional medicinal effects.

Researchers interested in Pseudostellarin G often seek other cyclic peptides from the Pseudostellaria heterophylla family, such as Pseudostellarin K, Pseudostellarin A, and its N-methylated analogs, which share structural similarities and potential bioactivities like antifungal and anthelmintic properties. Additionally, bioactive peptides from the same plant, including the immunomodulatory YG-9 peptide, are relevant for studies linking peptide structure to immunological effects. Beyond Pseudostellaria derivatives, broader cyclic peptide classes like polymixins, gramicidins, and oxytocin are of interest for comparative research into peptide pharmacology and therapeutic potential. If you are interested in related products, you can directly contact us or use our product customization service.