Swinholide A • Swinholide A is a marine-derived actin-binding polyketide that dimerizes actin with a dissociation constant (Kd) of approximately 50 nM. It disrupts microfilaments by stabilizing actin dimers and severing filaments, ultimately disturbing the actin cytoskeleton in cells. This compound also exhibits notable antifungal properties.
| CAS No. | 95927-67-6 |
| Purity | 98.30% |
| Molecular Weight | 1389.87 |
| Formula | C78H132O20 |
| Appearance | Liquid (Density: 1.15±0.1 g/cm3) |
| Color | Colorless to light yellow |
| SMILES | C[C@H]([C@](OC(/C=C/C(C)=C/C[C@@H](C[C@@](C=CC1)([H])O[C@]1([H])C[C@@H]([C@H]([C@H](C[C@H]([C@@H]2C)O)O)C)OC)O)=O)([H])[C@H]([C@@H](C[C@@H]([C@@H]([C@H](C[C@@]3([H])O[C@@](C[C@H](C/C=C(/C=C/C(O[C@]2([H])[C@@H](C)[C@@H](O)[C@@H](C)CC[C@H](O[C@H]4C)C[C@@H](C4)OC)=O)C)O)([H])C=CC3)OC)C)O)O)C)[C@@H](O)[C@@H](C)CC[C@H](O[C@H]5C)C[C@@H](C5)OC |
| Intended Use | For research use only. |
| Shipping | Room temperature |
| Storage |
Pure form -20°C, 3 years In solvent: -80°C, 6 months; -20°C, 1 month |
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